The National Innovation and Start-up Policy (NISP) is a guiding framework to enable the Higher Education Institutions to actively engage students, faculties, and staff in innovation and entrepreneurship-related activities. The All-India Council of Technical Education (AICTE) released a Startup Policy document for AICTE approved institutions during November 2016, to address the need of inculcation of innovation and entrepreneurial culture in higher education Institutions (HEIs). In 2019, MOE’s innovation cell (MIC) reformulated the AICTE startup policy as National Innovation and Start-up Policy (NISP) as a guideline for all Higher Education Institutions (HEI). The MIC conducted various eye-opener workshops and training programs for the HEI to join the NISP framework to formulate their own start-up policies in line with the protocols streamlined by the MIC. St joseph’s is a frontrunner to promote an environment, where the students and faculties can explore their start-up business ideas. The St Joseph’s Institution Innovation Council dedicated to cultivating the research practices and to construct the institution as one among the hubs in Tamilnadu to promote startup and entrepreneurship. St joseph’s short-term goal is to construct incubation facilities for fostering innovation and startups among the students and faculty members and our long-term goals is to attract start-ups from the external players and to develop at least 10 start-ups in next five-year time. St joseph’s start-up policy is the brainchild of a dedicated a NISP coordinator and the steering committee. St joseph’s adopted the NISP in the year 2021.